Objective To investigate the effect of alprostadil on oxidative stress in acute myocardial infarction patients treated by emergency percutaneous coronary intervention ( PCI) . Methods Ninety - nine acute myocardial infarction patients with emergency PCI were randomly assigned into two groups. Control group (48 patients) were treated with conventional hydration therapy, while experimental group (51 patients) were given with 10 μg alprostadil in 20 mL sodium chloride solution before conventional therapy qd for 7 days. The SCr levels, SOD activity and MDA concentration at 24th hour, 48th hour, 72nd hour, and on 7th day were assessed. Results There was no significant difference in SCr level, SOD activity or MDA content between the two groups 24 hours after therapy ( P＞0. 05 ) . The SCr levels were significantly lower in experimental group 48 hours, 72 hours and 7 days after therapy than those in control group ( P＜0. 05 ) . Meanwhile , significant elevation of SOD activity and reduction in MDA content were revealed in experimental group 72 hours and 7 days after therapy, when comparing with those in control group ( P＜0. 05 ) . Conclusion Alprostadil can ease the oxidative stress in acute myocardial infarction patients treated by emergency PCI, and reduce the incidence of contrast - induced nephropathy.%目的 观察前列地尔对行急诊经皮冠状动脉介入术(PCI)的急性心肌梗死患者氧化应激作用的影响.方法 将99例拟行急诊PCI的急性心肌梗死患者随机分为两组,对照组(48例)给予常规水化治疗;观察组(51例)在常规水化治疗的基础上于术前30 min开始给予10 μg前列地尔+0.9%氯化钠溶液20 mL静脉注射,1次/d,连续7 d.观察两组患者术后24、48、72 h及7 d的血清肌酐(SCr)水平、超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量.结果 两组患者术后24 h SCr水平、SOD活性和MDA含量比较差异均无统计学意义(P>0.05).术后48、72 h及7 d,观察组SCr水平均明显低于对照组(P<0.05).术后72 h及7 d与对照组比较,观察组患者血清SOD活性增加,MDA含量下降,差异有统计学意义(P<0.05).观察期间未发现明显药物不良反应.结论 前列地尔可改善行急诊PCI的急性心肌梗死患者的氧化应激状态,有可能减少此类患者造影剂肾病的发生率.
展开▼
