Objective To study the effects of Man Pen Zhu Yu decoction on hlood rheology and histology in rats with chronic pelvic inflammatory disease ( CPID ). Methods CPID was induced with bilateral uterine injection of mixed bacteriae, while sham operation was performed in control group. Blood theology and pathological changes were examined.Results Chronic inflammatory change was observed in model group, with significantly increase in blood rheologic parameters ( P ＜ 0. 01 ). However, significant improvement of pathological and rheologic status was revealed in groups of both middle and high dosage of Pen Zhu Yu decoction ( P ＜ 0. 05 ), comparing with both model and Fu Ke Qian Jin Jiao Nang groups. Conclusion Man Pen Zhu Yu decoction is promising on treating CPID in rat.%目的 研究慢盆逐瘀汤对慢性盆腔炎(CPID)大鼠血液流变学及病理组织形态学的影响.方法用混合菌接种法诱导大鼠CPID动物模型,其中假手术组仅打开腹腔,不注射混合菌,实验结束后取血进行血液流变学检测,子宫肉眼观察后进行病理组织学检查.结果 模型组病理组织形态学检查显示慢性炎症改变,CPID模型大鼠血液流变学各项指标较假手术组显著升高(P<0.01),慢盆逐瘀汤高、中剂量组对大鼠子宫病理组织形态学及血液流变学各项指标较模型组均显著改善(P<0.05),且优于妇科千金胶囊组.结论 慢盆逐瘀汤对大鼠CPID模型有理想的治疗效果.
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