目的 观察慢性应激抑郁症大鼠血清白介素(IL)-2、IL-6以及褪黑激素表达的变化.方法 20只SD大鼠随机分为对照组和模型组各10只,采用慢性不可预见性轻度应激法干预模型组,对照组不给予任何干预.比较两组干预后体重、强迫游泳静止时间、糖水偏好指数和血清IL-2、IL-6、褪黑激素的表达.结果 干预后,模型组大鼠体重、糖水偏好指数均低于对照组,强迫游泳静止时间长于对照组(均P<0.05);模型组大鼠IL-6水平高于对照组,而褪黑激素水平低于对照组(均P<0.05).结论 高水平的IL-6和低水平的褪黑激素可能与抑郁症的发病有关.%Objective To observe the changes of interleukin(IL)-2,IL-6 and melatonin expressions in rats with chronic stress depression.Methods Twenty SD rats were randomly divided into control group(n=10) and model group(n=10).The model group was given intervention of chronic unpredictable mild stress,and no intervention was performed in the control group.After intervention,weight,immobile time of forced-swimming test,preference for sucrose solutions,expressions of serum IL-2,IL-6 and melatonin were compared between the two groups.Results After intervention,the rats in the model group had reduced weight,decreased preference for sucrose solutions and increased immobile time of forced-swimming test compared to the control group(all P<0.05),the IL-6 level was higher but the melatonin level was lower in the model group compared to the control group(all P<0.05).Conclusion Increased IL-6 level and decreased melatonin level might correlate with the onset of depression.
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