目的：探讨吲哚菁绿荧光导航技术联合亚甲蓝示踪在乳腺癌前哨淋巴结活检术中的临床应用价值。方法将127例cT1～3 N0 M0乳腺癌患者按随机数字表法分为吲哚菁绿组62例及联合组65例，分别应用吲哚菁绿和吲哚菁绿联合亚甲蓝作为淋巴示踪剂进行前哨淋巴结活检术。结果吲哚菁绿组定位成功率为95．2％（59／62），联合组定位成功率为98．5％（64／65），两组比较，差异无统计学意义（P＞0．05）。联合组检出前哨淋巴结（3．8±1．5）枚／例，多于吲哚菁绿组的（2．7±1．2）枚／例（P＜0．01）。结论吲哚菁绿是一种可靠的、操作简单的淋巴结示踪剂，与亚甲蓝联合应用可提高前哨淋巴结检出数量。%Objective To investigate the clinical value of fluorescence navigation technology with indocyanine-green(ICG) combined with mapping with methylene blue applied to sentinel lymph nodes biopsy ( SLNB) in breast cancer patients .Methods One hundred and twenty-seven patients with cT1-3N0M0 breast cancer were randomly divided into ICG group (n=62) and combination group(n=65).IGG group underwent SLNB by mapping with ICG ,while combination group underwent SLNB by mapping with ICG and methylene blue .Results The success rates of location in the ICG group and combination group were 95.2%(59/62) and 98.5%(64/65),respectively,which showed no statistical difference (P>0.05).The average number of sentinel lymph nodes detected in the combination group was more than that in the ICG group((3.8 ±1.5)/case vs.(2.7 ±1.2)/case,P<0.01).Conclusion ICG is a reliable and simply lymphatic mapping tracer.The combination of ICG and methylene blue can increase the detection amount of the sentinel lymph nodes .
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