目的：研究儿童过敏性紫癜（HSP）与幽门螺旋杆菌（HP）感染的相关性。方法选择从2011年5月至2013年9月于我院确诊的70例腹型过敏性紫癜患儿作为试验组，另选择60例健康小儿作为对照组，试验组患儿和对照组均采用尿素14C呼气检测方法检查HP感染情况，对试验组HP感染阳性患儿行胃镜检查，观察胃、十二指肠等病变情况。结果试验组的HP感染率65.7%，而对照组的HP感染率30.0%，两组HP感染率比较，差异有统计学意义（χ2=16.4874，P=0.0000），试验组18例HP感染阳性的患者中，17例患者在胃镜活检下发现胃黏膜病变，1例在胃镜活检下未发现黏膜病变。黏膜病变多表现为散在片状出血斑、糜烂出血等。发现十二指肠球部、降部病变发生率最高，胃窦、胃体其次、剩下依次为十二指肠水平部、胃底。结论 HP感染与儿童HSP发病有一定的相关性，HP感染阳性的HSP患儿存在不同程度的胃十二指肠黏膜病变情况。%Objective To analyze the correlation between Purpura in children and the infected with Helicobacter pylori. Methods 70 cases of allergic purpura in children were selected from May 2011 to September 2013 in our hospital as the test group, and the other 60 cases of healthy children as a control group, the experimental group and a control group of children were using 14C urea breath to check the HP infection, then the test group of HP infection were underwent endoscopy, and observed lesions of the stomach, duodenum and so on. Results The rate of HP infection in the test group was 65.7%, while that of the control group was 30.0%, comparison of the rate of the two HP infection,the difference was statistically signiifcant(χ2=16.4874, P=0.0000), patients with positive HP infection in test group were 18 patients, while 17 patients were found that gastric lesions in endoscopic biopsy, only 1 case were found no mucosal lesions in endoscopic biopsy. Mucosal lesions showed scattered lfakes bleeding spots, erosion and bleeding. Found duodenal descending lesions highest incidence of gastric antrum, body followed, and the rest were duodenum, gastric fundus. Conclusions HP infection and the HSP children have some relevance, HP positive infections in children with varying degrees of gastroduodenal mucosal lesions.
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