Objective This study compared the adhesion of oral streptococcus mutans to Ti-6Al-4V alloy and Chromium-Cobalt alloy in vitro, and studied the correlation between surface roughness and bacteria adhesion. Methods The quantiifcation of the attached bacteria on the surfaces of the material was assayed by means of clone forming unit (CFU)method 24, 48, 168 hours after the bacteria were seeded onto the Ti-6Al-4V alloys and Chromium-Cobalt alloys of the different surface roughness. Result The quantiifcation of the attached bacteria on the surfaces of Ti-6Al-4V alloy is more than Chromium-Cobalt alloy with the increans of roughness, bacteria adhered on two kinds of sample improved in amount. Conclusion Compared with Chromium-Cobalt alloy, Ti-6Al-4V alloy can decrease the complication caused by attached bacteria, further more, grinding and polishing the surface of the prothesis can reduce the complication caused by attached bacteria.%目的：比较钛合金（Ti-6Al-4V）和钴铬合金（Chromium-Cobalt alloy）表面口腔变形链球菌黏附能力的大小，研究表面粗糙度与细菌黏附的关系。方法将不同表面粗糙度的钛合金和钴铬合金试件进行变形链球菌体外黏附试验，采用菌落形成计数法测定试件表面的细菌黏附量。结果钛合金组的细菌黏附量少于钴铬合金组。二者的细菌黏附量均随表面粗糙度的增大而增加。结论钛合金较钴铬合金更利于减少由细菌引起的并发症，同时修复体表面严格的研磨抛光也能有效减少由细菌引起的并发症。
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