Objective To explore multi-slice CT manifestations and value of diagnosis of pulmonary invasive fungal infection(IPFI) during chemotherapy in leukemia.Methods 18 patients of IPFI were enrolled in this investigation, of which CT manifestations and clinical features were observed retrospectively. Results 13 cases were found focuses in both sides of the lung, right lung 3 cases, left lung 2 cases. All the cases had deifnite microbial examinations, which included nine cases of aspergillus which was the most common pathogenic fungus, two cases of candida albicans and two cases of candida krusei. Seven cases were examined with CT after treatment more than twice. Lesions tended to distribute in lung peripheral zone and subpleural area. The common CT ifndings of IPFI were solitary or multiple nudles or mass, pulmonary consolidation, ground glass opacity, halo sign, cavities or air-crescent sign in lungs.Conclusion Multi-slice CT diagnosis of pulmonary invasive fungaI infection during chemotherapy in leukemia is worthwhile in clinical intervention and observation.%目的：探讨MSCT在血液病并发肺部侵袭性真菌感染的CT特征及诊断价值。方法对18例血液病患者治疗中并发肺部侵袭性真菌感染的CT影像表现进行回顾性分析。结果病灶位于双肺13例，右肺3例，左肺2例。所有病例都有明确微生物学检查，病源菌以曲霉菌9例者最为常见，其次白色念珠菌7例，克柔假丝酵母菌2例。7例行2次以上CT复查。病变多分布于肺野外带及胸膜下，CT影像学表现为单发、多发结节状、肺实变、磨玻璃样改变、晕征、空洞、空气半月征。结论 MSCT在血液病治疗中并发肺部真菌感染的诊断中具有重要价值。
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