Objective To study the signiifcance of CCR5 and c-Met expression in breast cancer.Methods The expression of CCR5 and c-Met in 45 cases of breast cancer was analyzed by using immunohistochemisty. Results CCR5 was expressed in 55.6% of cancerous breast tissue (25/45), whereas it was only expressed in 8.9% of normal breast tissue (4/45). Signiifcant difference was noted between the expression levels (P<0.01). c-Met was expressed in 51% of cancerous breast tissue (23/45), but only 6.6% (3/45) of normal tissue. The observed difference in expression level of c-Met was also statistically signiifcant (P<0.01). On the other hand, 44.4% (20/45) of breast cancer patients with lymph node metastasis showed co-expression of both c-Met and CCR5, compared to 22.2% (10/45) in the normal breast tissue. Our ifndings demonstrate signiifcant associations between the expression of c-Met, CCR5 and lymph node metastasis in breast cancer patients. Conclusion CCR5 and c-Met expression was associated with poor prognosis of breast cancer patients, which could be predict the prognosis of breast cancer.%目的：探讨乳腺癌组织中CCR5和c-Met的表达及其意义。方法采用免疫组化SP法检测45例乳腺癌中CCR5和c-Met的表达。结果乳腺癌组织CCR5阳性率55.6%（25/45），正常乳腺组织中CCR5表达率8.9%（4/45），两种组织阳性表达率差异显著（P<0.01），c-Met的阳性表达率为51%（23/45），正常乳腺组织中c-Met表达率6.6%（3/45），两种组织阳性表达率差异显著（P<0.01）。在伴有淋巴结转移的乳腺癌中c-Met和CCR5的共同阳性率44.4%（20/45），无淋巴结转移的乳腺癌中阳性表达率为22.2%（10/45）。CCR5和c-Met的表达和乳腺癌的淋巴结转移成正相关。结论CCR5和c-Met与提示乳腺癌的转移预后因素有关，可作为预测乳腺癌转移的参考指标之一。
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