目的探讨胰岛素泵强化治疗对初诊2型糖尿病患者胰岛功能的保护作用.方法初诊2型糖尿病患者44例随机分为两组，分别给予胰岛素泵强化治疗(CSII 组)和多次皮下胰岛素注射(MSII 组)治疗2周.比较两组治疗前后空腹血糖(FPG)、餐后2h 血糖(2hPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、胰岛素抵抗指数(HOMA-IR)、C 反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平.结果 MSII 组和 CSII 组治疗后 FPG、2 hPG、HbA1c、TC、TG、LDL-C、HDL-C、HOMA-IR、CRP、TNF-α均较治疗前明显下降(P<0.05).CSII 组治疗前后变化量明显高于MSII 组(P<0.05).结论胰岛素泵短期强化治疗不仅能平稳降糖，还具有降脂、改善氧化应激及减少炎症的作用，从而达到改善β细胞功能及胰岛素抵抗的目的.% Objective Through the observation short-term insulin pump therapy intensified (CSII) and multiple subcutaneous insulin injection (MSII) , before and after blood sugar, blood fat, inflammation factors, insulin resistance index change, this paper discusses the insulin pump first visit to patients with type 2 diabetes mellitus beta cell protection. Methods First visit in patients with type 2 diabetes in 44 patients randomly divided into two groups, namely give insulin pump (CSII group) and multiple subcutaneous insulin injection (MSII group) treatment 2 weeks. Compared between the two groups before and after treatment fasting plasma glucose (FPG), postprandial 2h blood sugar (2HPG), glycated hemoglobin(HbA1c),total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL)-C), high-density lipoprotein cholesterol (HDL-C), insulin resistance index (HOMA-IR), c-reactive protein (CRP), tumor necrosis factor alpha (TNF alpha) level. Results MSII group and CSII group after treatment FPG, 2 hPG, HbA1c, TC, TG, LDL - C, HDL-C, HOMA-IR and CRP, TNF alpha than before treatment decreased obviously (P<0.05). CSII group variation before and after treatment significantly higher than MSII group (P< 0.05). Conclusion Insulin pump short-term intensie treatment not only has the stationary hypoglycemic effect, still have fall fat, improve oxidative stress and reduce the role of inflammation, so it can improve ss-cell function and the role of insulin resistance.
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