目的观察经阿霉素(ADR)作用的实验大鼠心肌组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、黄嘌呤氧化酶(XOD)含量的变化.方法采用36只 Wistar 雌性大鼠,分生理盐水(NS)组和 ADR 组,ADR 组尾静脉缓慢注射 ADR(3mg/kg),每周一次；NS 对照组尾静脉及腹腔注射等剂量 NS.分别用药三周和六周后处死,观察各组大鼠心肌组织中 MDA、SOD、GSH 及 XOD含量的变化.结果 ADR 组 MDA 与 XOD 含量均升高,SOD 与 GSH 含量均下降.结论过氧化反应增强、自由基生成酶活性升高及清除酶或清除剂活性降低可能参与了 ADR 心脏损伤的发生.% Objective To observe the changes of the contents of MDA、SOD、XOD and GSH in cardiac homogenate.Methods Tirty-six healthy female Wistar-rats were adopted. ADR was administered slowly by caudal vein injection (3mg/kg body weight) once a week in ADR group. Control rats received equivalence saline by caudal vein injection. These rats were sacrificed separately after three weeks and six weeks. We observed and compared the changes of the contents of MDA,SOD,GSH and XOD in cardiac homogenate. Results Compared with the NS group,the increased contents of MDA and XOD in cardiac homogenate were found in ADR group. Conclusion Peroxidation and the increased activity of the enzymes which produce the free radicals and the decreased activity of the enzymes which eliminate the free radicals involved the occurrence of the adriamycin -induced cardiotoxic.
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