目的：探讨特发性肺纤维化（IPF）的发病机制以及 IPF 患者凝血指标与肺功能的相关性。方法将32例特发性肺纤维化患者设为观察组，32例健康人设为对照组，检查两组研究对象的血凝指标、肺高分辨率 CT 及肺功能，并进行比较和相关性分析。结果 IPF 患者血液中 D‐二聚体、血浆纤维蛋白原含量升高；血浆纤维蛋白原水平与肺一氧化碳弥散量（DLCO）水平呈显著负相关性。结论 IPF 患者体内处于血液高凝状态，血浆纤维蛋白原（FIB）含量检测能够反映肺弥散能力，进一步判断肺纤维化的病情轻重。%Objective To explore the pathogenesis of idiopathic pulmonary fibrosis and the corre‐lation between hemagglutination index and pulmonary function .Methods 32 cases of patients with idio‐pathic pulmonary fibrosis were set as observation group ,32 healthy people were set as the control group .The hemagglutination index ,pulmonary high‐resolution CT and pulmonary function of two groups were examined ,then statistical analysis were conducted .Results The levels of plasma D‐dimer and fibrinogen increased in patients with idiopathic pulmonary fibrosis .Plasma fibrinogen levels and DLCO were significantly negatively correlated .Conclusion Hypercoagulable state occurs in patients with idiopathic pulmonary fibrosis .The fibrinogen levels in the blood can prompt the pulmonary diffu‐sion function ,and thus reflect the severity of disease .
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