Objective To investigate the effect of vitamin D supplementation an adjuvant therapy on serum tu-mor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with nonalcoholic fatty liver disease (NAFLD). Methods A total of 62 cases of NAFLD patients treated in Gastroenterology Department of our hospital from January 2015 to February 2016 were investigated. They were randomly divided into two groups based on the random number table (31 patients in each group):the control group were treated with oral Polyene Phosphatidyl-choline (PPC) capsules, the observation group were treated with combined PPC/vitamin D preparations, the course of treatment was 12 weeks. The changes of serum TNF-α, IL-6 and CRP were compared between the two groups before and after treatment. Results In observation group, the levels of serum TNF-α, IL-6 and CRP after treatment were (37.24 ± 12.74) ng/L, (29.45 ± 7.18) ng/L, (5.39 ± 1.46) mg/L, respectively, which were significantly lower than those be-fore treatment (P<0.05). Compared with (65.39 ± 18.37) ng/L, (44.22 ± 16.01) ng/L, (8.67 ± 2.34) mg/L in the control group, the decline were more obvious (P<0.05). There was no significant difference between the levels of serum TNF-α, IL-6 and CRP in the control group before and after treatment (P>0.05). Conclusion The Vitamin D supplementation as an adjuvant treatment for patients with NAFLD can regulate the levels of TNF-α, IL-6 and CRP in serum.%目的 探讨维生素D辅助治疗对非酒精性脂肪性肝病(NAFLD)患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及C反应蛋白(CRP)水平的影响.方法 选择我院肝病科于2015年1月至2016年2月期间诊治的62例NAFLD患者为研究对象,根据随机数字表法随机分为两组,每组31例.对照组患者予口服多烯磷脂酰胆碱胶囊治疗,观察组患者联合应用维生素D治疗,疗程均为12周.比较两组患者治疗前后血清TNF-α、IL-6及CRP的变化.结果 观察组患者治疗后血清TNF-α、IL-6及CRP水平分别为(37.24±12.74)ng/L、(29.45±7.18)ng/L、(5.39±1.46)mg/L,均较治疗前明显降低,差异均有统计学意义(P<0.05),且与对照组的(65.39±18.37)ng/L、(44.22±16.01)ng/L及(8.67±2.34)mg/L比较,降低更明显,差异均有统计学意义(P<0.05);而对照组患者治疗后的TNF-α、IL-6及CRP与治疗前比较差异均无统计学意义(P>0.05).结论 维生素D辅助治疗非酒精性脂肪性肝病可调节患者血清TNF-α、IL-6及CRP水平.
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