Cerebral ischemia injury and Parkinson's disease ( PD) are the aging-related diseases found to develop often in the central nervous system ( CNS) .Neuroinflammation is one of the critical pathological changes of cerebral ischemia and PD.The 5-lipoxygenase ( 5-LOX ) is a key enzyme metabolizing arachidonic acid to produce potent proinflammatory mediators cysteinyl leukotriene (CysLTs).Recent studies have shown that 5-LOX is involved in the pathological process of cerebral ischemia and PD .%脑缺血损伤和帕金森病（Parkinson's disease，PD）是中老年人常见的中枢神经系统疾病，神经炎症是脑缺血和帕金森病的基本病变。5-脂氧酶（5-LOX）是炎症介质半胱氨酰白三烯（ CysLTs）合成的限速酶。最近的研究已经表明，5-LOX在脑缺血损伤和PD病理过程中发挥重要的调节作用。
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