Objective To investigate the levels and clinical significance of serum heparin binding protein(HBP) in patients with chronic obstructive pulmonary disease (COPD) at acute stage and stable stage.Methods Eighty patients with COPD were enrolled in the study.The serum levels of HBP and WBC,CRP and PCT were detected,and the blood albumin and depressive state of patients were observed,moreover,the correlation between pulmonary function and HBP was analyzed. Results The inflammatory indexes including HBP in COPD patients at acute stage were significantly higher than those of patients at stable stage(P<0.05),and there was a close correlation between HBP and WBC,PCT and CRP of patients at acute exacerbation stage and stable stage(P<0.05).The sputum volume of patients was concordant with HBP at acute stage. Besides there was a significant correlation between HBP and pulmonary function (FEV1), depression state,anxiety scores, blood albumin levels of hospitalized patients(P<0.05).Conclusion The levels of HBP are significantly increased in COPD and acute exacerbation of COPD,which are closely correlated with the other inflammatory factors,pulmonary function, depression state and hypoproteinemia,therefor,HBP is an important inflammatory factor of COPD.%目的 探讨急性期和稳定期慢性阻塞性肺疾病(COPD)患者血清肝素结合蛋白(HBP)的水平和临床意义.方法 纳入80例COPD患者,分别测定血HBP和白细胞、CRP、PCT等炎性指标,观察稳定期肺功能与HBP的关系,观察住院患者血白蛋白和抑郁状态.结果 AECOPD患者在急性加重期时HBP等炎性指标明显高于患者的稳定期(P<0.05);在急性加重期和稳定期,HBP与患者WBC、PCT、CRP之间有较强的相关(P<0.05),HBP与急性期患者痰量也有一致性(P<0.05);HBP与患者肺功能FEV1有明显的相关性(P<0.05);患者HBP与患者住院抑郁焦虑评分、血白蛋白水平相关(P<0.05).结论 HBP在COPD和AECOPD时明显升高,与患者其他炎性因子、肺功能、抑郁状态、低蛋白血症相关,HBP是COPD一种重要的炎性因子.
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