Objective To investigate the role of serum VEGF-A, sFlt-1, MDA and T-AOC in patient with preeclampsia. Methods Twenty-eight woman patients with severe preeclampsia who were hospitalized in our hospital from May to December 2014 were enrolled as preeclampsia group ( group PE) ,at the same time, 20 normal pregnant women were enrolled as control group. The serum levels of VEGF-A and sFlt-1 were detected by enzyme-linked immunosorbent assay ( ELISA) ,and the serum levels of MDA and T-AOC were measured by chemical method. Results As compared with those in control group, the serum levels of VEGF-A were significantly decreased in group PE, however,the serum levels of sFlt-1 were significantly increased in group PE (P<0. 05),moreover the MDA levels in group PE were significantly higher than those in control group,but T-AOC levels were significantly lower than those in control group (P<0. 05). In addition the serum levels of VEGF-A in group PE were positivelt correlated with neonatal birth weight and placental weight (P<0. 05). Conclusion The serum levels of MDA,VEGF-A,sFl-1and T-AOC in patients with preeclampsia are changed significantly,which suggests that dysfunction of vascular factor and oxidative stress are involved in the pathogenesis of preeclampsia.%目的 探讨血清血管内皮生长因子-A(VEGF-A)、可溶性血管内皮生长因子(sFlt-1)、MDA及T-AOC在子痫前期发病中的作用.方法 选取2014年5至12月住院分娩重度子痫前期孕妇28例作为子痫前期组,同期正常孕妇20例为对照组.采用酶联免疫吸附试验检测血清VEGF-A和sFlt-1水平,化学法检测血清MDA及T-AOC水平.结果 (1)PE组血清VEGF-A水平比N组减低,sFlt-1水平比N组增高,MDA水平比N组高,T-AOC水平比N组低,差异有统计学意义(P<0.05).(2)PE组血清VEGF-A水平与新生儿出生体重及胎盘重量呈正相关(P<0.05).结论 子痫前期患者外周血清VEGF-A、sFlt-1、MDA及T-AOC水平发生显著变化,说明血管因子功能紊乱及氧化应激均参与了子痫前期的发病.
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