目的 讨论血浆PZ含量与早发型子痫前期的相关性及其临床指导意义.方法 选择早发型子痫前期患者(孕周28~34周)80例,相同孕周正常晚期妊娠孕妇40例、正常早孕、中孕及非孕育龄女性各40例;采用ELISA定量测定血浆蛋白Z(PZ)水平;采用t检验分析比较各项指标水平的差异及其相关性.结果 正常育龄非孕女性及正常早、中、晚期孕妇血浆PZ随着妊娠及孕周的增加,逐渐升高,差异有统计学意义(P<0.05);早发型子痫前期组患者血浆PZ含量与正常晚期妊娠组比较显著降低,差异有统计意义(P<0.05);早发型子痫前期重度与轻度患者相比血浆中PZ含量明显下降,差异有统计学意义(P<0.05).结论 血浆PZ在正常妊娠状态下较非孕期升高且随孕周增加呈现上升趋势;血浆PZ降低可能与早发型子痫前期发病相关;早发型子痫前期的严重程度与血浆PZ含量相关.%Objective To investigate the correlation between plasma protein Z ( PZ ) content and early-onset preeclampsia, and to explore its clinical significance. Methods Eighty patients with early-onset preeclampsia( gestational weeks 28 ~ 34, preeclampsia group), 80 normal late-pregnancy women( gestational weeks 28 ~ 34 ,late pregnancy group ) ,40 normal prepregnancy women,40 normal midtrimester pregnancy and 40 normal non-pregnant reproductive life women were enrolled in the stud)'. The levels of PZ were detected by ELISA, and the data were statistically analyzed. Results The plasma PZ levels in normal non-pregnant reproductive life women and in normal early, middle, late term pregnant women were increased with the gestational weeks, and the differences were statistically significant P < 0. 05 ). The plasma PZ levels in preeclampsia group were significantly decreased,as compared with those in normal late pregnancy group( P < 0. 05 ). The plasma PZ levels in severe preeclampsia women were significantly decreased, as compared with those in mild preeclampsia women( P < 0.05 ). Conclusion The plasma PZ levels in normal pregnancy women are higher than those in normal non-pregnant reproductive life women,which increase with the gestational weeks. The decrease of plasma PZ levels may be related with the pathogenesis of early onset preeclampsia, and the severity of early onset preeclampsia is related to plasma PZ levels.
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