目的:探讨血清基质金属蛋白酶-7(MMP-7)及糖类抗原19-9(CA19-9)联合检测对早期鉴别胰腺癌与慢性胰腺炎的意义.方法:选取胰腺癌患者27例,慢性胰腺炎患者34例,同期体检正常者30例(对照组)作为研究对象.MMP-7测定采用ELISA法,CA19-9测定采用化学发光免疫法.结果:胰腺癌组血清MMP-7水平显著高于慢性胰腺炎组及对照组(P均<0.05).胰腺癌组、慢性胰腺炎组血清CA19-9水平显著高于对照组(P均<0.05),胰腺癌组和慢性胰腺炎组比较无显著差异.血清MMP-7和CA19-9的ROC曲线下面积分别为0.796和0.668.两者联合诊断对胰腺癌的敏感性、特异性分别为85.3%和70.4%.结论:血清MMP-7测定可用于胰腺癌的诊断,联合检测CA19-9可提高胰腺癌的敏感性,同时有助于鉴别胰腺癌与慢性胰腺炎.%Objective:To investigate the vsignificance of combined detections of MMP-7 and CA19-9 in differential diagnosis between chonic pancreatitis and pancreatic cancer.Methods:27patients with pancreatic cancer,34 patients with chronic pancreatitis were chosen as research groups,and 30 healthy subjects were selected as the control group.The levels ofMMP-7 andCA19-9 were measured by using ELISA and chemistry luminescence technique.Results:The serum levels of CA19-9 in pancreatic cancer group and chonic pancreatitis group were statistically significantly higher than those in control group (P<0.05).But there are no significantly statistical differences in comparison between pancreatic cancer group and chonic pancreatitis group.The serum levels of MMP-7 in pancreatic cancer group were statistically and significantly higher than those in pancreatitis group and control group (P<0.05).The areas under ROC curve of serum MMP-7 and CA19-9 were 0.796 and 0.668,respectively.The sensitivity and specificity of joint detection of serum MMP-7 and CA19-9 were 85.3% and 70.4%,respectively.Conclusion:The joint detection of serum MMP-7 and CA19-9 can be used for differential diagnosis between chonic pancreatitis and pancreatic cancer,which can significantly increase the detection rate of pancreatic cancer.
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