通过探讨慢性阻塞性肺疾病急性加重期(AECOPD)血清8-羟基脱氧鸟苷酸(8-OHdG)和锰超氧化物歧化酶(MnSOD )水平的特点，相关分析其与BODE指数的关系。选择AECOPD患者96例，健康对照组90例，检测血清8-OHdG水平及MnSOD水平，与AECOPD患者BODE指数进行相关分析。结果发现：与健康对照组比较，AECOPD患者血清8-OHdG升高、MnSOD降低，差异有显著性（p<0.05）。AECOPD患者血清8-OHdG与MnSOD呈负相关（p<0.01）；血清8-OHdG与BODE指数正相关（p<0.01），血清MnSOD与BODE指数负相关（p<0.01）。说明8-OHdG与MnSOD水平的变化与AECOPD的病情严重程度相关。%To analyze the relationship of serum 8-OHdG,MnSOD levels and BODE indexes in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD),and investigate the clinical value of serum 8-OHdG and MnSOD in evaluating disease severity and prognosis. A comparative study was performed in 96 AECOPD patients and 90 matched healthy individuals. The serum levels of 8-OHdG and MnSOD in both groups were measured.Correlation analysis was performed between serum 8-OHdG,MnSOD levels and BODE indexes in the patients with AECOPD. The serum 8-OHdG concentrations were higher, serum MnSOD concentrations were lower in patients with AECOPD compared with those in control subjects. There were statistical significances (p<0. 01). MnSOD levels were correlated negatively with 8-OHdG levels in patients with AECOPD (p<0.01). 8-OHdG levels were correlated positively with BODE indexes. MnSOD levels were correlated negatively with BODE indexes. Detection of serum 8-OHdG and MnSOD can help evaluate the severity of COPD.
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