Objective To determine the effectiveness of minocycline on peri -implantitis reported by articles and to assess the quality of the studies by evidence -based medicine.Methods The data bases such as CNK,wanfangdata,VIP,Web of Science,MEDLINE,Science Direct,Springer Link published were searched.Collect all published literatures about the treatment of peri -implantitis with minocycline.Literatures were screening and the data were extracted in accordance with inclusion crite-ria.Analyze literature based on evidence -based medicine.Results There were totally 1 3 articles that met the criteria.Ran-domized Controlled trials(RCT)was in a small number.Meta -analysis could not be done.The results showed that:for now, the treatment of peri -implantitis with minocycline had a good effect.Conclusion The quantity and quality of the research liter-ature on the treatment of peri -implantitis with minocycline can not meet the clinical needs.Further trials of high quality need to be undertaken in order to provide the best evidence for treatment of peri -implantitis.%目的：运用循证医学的方法评价盐酸米诺环素治疗种植体周围炎的疗效及其研究质量。方法计算机检索中国知网、万方数据库、维普数据库、Web of Science、MEDLINE、Science Direct 和 Springer Link 中有关盐酸米诺环素局部应用治疗种植体周围炎的文献。按纳入和排除标准筛选文献，进行方法学评价并整理文献，按照循证医学的方法进行分析。结果共检索到文献13篇，符合随机对照试验标准的文献有2篇，文献的数量较少，无法进行 Meta 分析。据纳入的文献分析结果得知，局部应用盐酸米诺环素在治疗种植体周围炎症时，有很好的疗效。结论目前，盐酸米诺环素治疗种植体周围炎症疗效的研究文献数量和质量不能满足临床需求，需要更多更科学的随机对照试验研究文献，指导盐酸米诺环素对种植体周围炎症的治疗。
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