真菌来源的活性天然产物为药物研发过程提供结构新颖、活性优良的先导化合物,因此在药物开发过程中具有重要的作用.真菌来源的二倍半萜类化合物terpestacin,是由一个十五元环和一个五元环稠合而成的双环化合物.由于其在具有抗癌、抗HIV等方面的活性,被认为是一种非常有前景的抗癌和抗HIV药物的先导化合物.因此自其被发现以来,科研工作者对该类化合物的生物活性、生物合成及化学合成方面开展了很多研究.本文收集了来自1993年以来关于terpestacin的文献报道,对该类化合物的生物来源、活性、生物合成途径及化学合成研究进行了简要综述.%The fungal metabolites,a kind of important compounds in the research and development of drugs for the novel structure and pretty bioactivity. Terpestacins,a kind of sesterpenoid from fungi,was structured with fifteen-membered ring and five-membered ring. For the interesting biological activities at anti-cancer,and anti-HIV,terpestacin was a potential lead compound for the development drugs of anticancer as well as anti-AIDS chemotherapeutics. Many researches on bioactivities biosynthesis and chemical synthesis of terpestacin have been conducted. This review focuses on the biological sources for the production,bioactivities biosynthesis and chemical synthesis of terpestacin on basis of the researching the literatures from the year 1993.
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