Objective To investigate the correlation between the use density of antibiotic and antifungal drugs and the positive rate of aspergillus in our hospital from 2009 to 2013,in order to provide a scientific basis for rational use of antibiotic and antifungal drugs. Methods The use density of carbapenems,two third-generation cephalosporins,and antifungal drugs,and the positive rate of aspergillus in our hospital from 2009 to 2013 were studied retrospectively. Their correlation was analyzed using SPSS software. Results There was significantly positive correlation between the use density of imipenem and that of fluconazole (r=0.913,P<0.05).The use density of biapenem was positively correlated with that of voriconazole (r=0.915,P<0.05).The use density of biapenem and that of voriconazole was positively correlated with positive rate of aspergillus,respectively ( r=0.918,r=0.955,both P<0.05).The other antibiotic and antifungal drugs were not significantly correlated to the positive rate of aspergillus.%目的：对抗菌药物和抗真菌药物使用强度与曲霉菌阳性率变化进行相关性分析，为抗菌药物及抗真菌药物的合理使用提供参考依据。方法回顾性分析我院2009—2013年碳青霉烯类抗菌药物和2种第3代头孢菌素使用强度、4种抗真菌药物使用强度和同期曲霉菌培养阳性率，用SPSS软件分析相互之间的相关性。结果5年中亚胺培南的使用强度与氟康唑的使用强度之间有显著正相关性，相关系数r＝0.913( P<0.05)；比阿培南的使用强度与伏立康唑的使用强度有显著正相关性，r＝0.915(P<0.05)；比阿培南的使用强度与曲霉菌阳性率有显著正相关性，r＝0.918(P<0.05)；伏立康唑的使用强度与曲霉菌阳性率有显著相关性，r＝0.955( P<0.05)；其他抗菌药物、抗真菌药物使用强度与曲霉菌阳性率无显著相关性。结论合理控制抗菌药物的用药强度可能使抗真菌药物的使用强度及曲霉菌感染率下降。
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