目的 探讨新疆地区布鲁氏菌病流行情况、临床特征、相关检查及治疗转归情况.方法 回顾性分析新疆医科大学第一附属医院2005年1月-2012年9月收治的153例布鲁氏菌病住院患者的一般情况、临床特征及治疗转归情况.结果 新疆地区的布鲁氏菌病有较为明显的职业特点,每年的4-8月高发,近年发病数有增加趋势.患者症状以发热为主,同时伴有大汗、肌肉骨关节疼痛、肝大和脾大等临床表现,部分患者出现WBC、HGB及PLT不同程度的下降,以及乳酸脱氢酶异常.治疗以利福平+多西环素及利福平+左氧氟沙星为主,好转率达99.12％.结论 新疆地区为布鲁氏菌病的高发区,在接诊以“不明原因发热”为主诉的患者时,应考虑该疾病的可能..布鲁氏菌病发病率在我国有回升趋势,应引起高度重视.%Objective To investigate epidemiology, clinical characteristics, laboratory findings, treatment and outcome of patients with brucellosis in Xinjiang Uyghur Autonomous Region (Xinjiang). Method General data, clinical characteristics, treatment and outcome of 153 patients with brucellosis hospitalized in the First Affiliated Hospital of Xinjiang Medical University from Jan. 2005 to Sept. 2012 were analyzed retrospectively. Results The prevalence of brucellosis was higher in the population with certain occupations in Xinjiang. Brucellosis occurred mainly from April to August each year, and the number of patients with brucellosis had been growing in recent years. The main clinical manifestation was fever, accompanied by sweating, muscle and joint pain, hepatosplenomegaly and so on, while WBC, HGB and PLT decreased in defferent degrees and abnormal lactate dehydrogenase was found in some patients. The combination of rifampicin and doxycycline, or rifampin and levofloxacin achieved a high improvement rate (99.12%). Conclusions The prevalence of brucellosis is high in Xinjiang, so brucellosis should be considered when the patient presents with primary complaint of fever of unknown origin. The incidence of brucellosis is increasing in China, which should be paid much more attention.
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