目的:探讨雷珠单抗联合光动力疗法治疗年龄相关性黄斑变性对脉络膜新生血管(choroidal neovascularization,CNV)渗漏及视力的影响.方法:选取2012-01/2015-12在我院接受治疗的78例86眼年龄相关性黄斑变性患者作为研究对象,采用随机数字表分为联合组(雷珠单抗联合光动力疗法)39例42眼、对照组(单用雷珠单抗治疗)39例44眼,对比两组患者治疗前后的视力、CNV渗漏情况变化.结果:治疗后第6、12wk,联合组患者的最佳矫正视力(best corrected visual acuity,BCVA)测定值均大于对照组,差异具有统计学意义(P0.05).结论:雷珠单抗联合光动力疗法治疗年龄相关性黄斑变性对CNV渗漏、视力及CRT均具有较好的改善作用.%AIM:To investigate the effect of combination therapy with Ranibizumab and photodynamic therapy in the treatment of age-related macular degeneration.METHODS:Totally 78 cases (86 eyes) with age-related macular degeneration in our hospital from January 2012 to December 2015 were selected as the subjects.The patients were randomly divided into two groups,39 cases (42 eyes) were treated by combination as the combination group and 39 cases (44 eyes) as the control group (only treated with ranibizumab).The changes of visual acuity and choroidal neovascularization (CNV) leakage were compared between the two groups before and after treatment.RESULTS:After treatment for 6 and 12wk,the best corrected visual acuity (BCVA) value of the combined group was higher than that of the control group,the difference was statistically significant (P0.05).CONCLUSION:The efficacy of the combination therapy is good for CNV leakage,visual acuity and CRT in patients with age-related macular degeneration.
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