目的:探讨阿尔茨海默病(Alzheimer disease,AD)与青光眼发病机制的相关性.方法:前瞻性研究阿尔茨海默病患者24例48眼,年龄、性别匹配的正常人30例60眼,所有入选者C/D0.05).结论:AD患者眼压较正常偏低,可能对AD患者青光眼性视神经损伤是一种保护机制.%AIM:To investigate the correlation between Alzheimer`s disease (AD) and the pathogenesis of glaucoma.METHODS:Prospective observational study.Totally 24 AD subjects and 30 age-and sex-matched controls were enrolled.All of the subjects had a cup-to-disc ratio (CDR) less than 0.6 and asymmetry of less than 0.2 between right and left eyes.Retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness were obtained using Fourier domain optical coherence tomography.The intraocular pressure (IOP) was also measured.RESULTS:Mini-mental state examination (MMSE) scores were significantly higher in the AD group compared with controls (P0.05).CONCLUSION:Patients with AD have lower IOP,which suggesting a protection mechanism of optic nerve damage in AD patients.
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