目的:评价妥布霉素地塞米松眼膏治疗睑缘炎的疗效和安全性.方法:计算机检索Pubmed、Medline、Embase、Elsevier、Cochrane Library、万方、中国知网、中国科技期刊全文数据库、中国生物医学文献数据库等数据库,手工检索灰色文献,并用Google搜索相关文献.从有效率、眼压、不良反应等方面进行系统评价,并提取有效数据进行Meta分析.结果:共有8个符合要求的随机对照研究纳入,患者共970例.试验组和对照组比较结果显示试验组有效率高于对照组,差异具有统计学意义(RR=1.75,95％ CI=1.29 ～2.37,P=0.0003);试验组眼压高于对照组,差异具有统计学意义(SMD=1.30,95％CI=0.85～1.75,P＜0.00001);两组的不良反应(眼睑水肿、结膜充血、眼压升高、眼睑刺痒、过敏反应)差异无统计学意义(RR=1.64,95％ CI=0.86～3.10,P=0.13).结论:妥布霉素地塞米松眼膏治疗睑缘炎有效,且不增加治疗的不良反应.但由于纳入的文献总体质量不高,尚仍需严谨的高质量的随机对照试验进一步证实.%AIM:To investigate and evaluate the effectiveness and safety of tobramycin and dexamethasone ointment in the treatment of blepharitis.METHODS:We searched in Pubmed,Medline,Embase,Elsevier,Cochrane Library,Wangfang database,CNKI,VIP database,Sinomed database,and gray literature were performing manual.The efficiency,intraocular pressure,adverse reactions and extract valid data were evaluated.RESULTS:Totally 8 controlled trials were enrolled,including 970 patients.Compared with control groups,the efficiency and the intraocular pressure in experiment group had a statistically significant increase (RR=1.75,95％ CI=1.29-2.37,P=0.0003;SMD=1.30,95％ CI=0.85-1.75,P＜0.00001),and there was no statistic difference in adverse reactions (RR =1.64,95％ CI =0.86-3.10,P =0.13).CONCLUSION:Tobramycin and dexamethasone ointment in treatment of blepharitis is effective with no adverse effects.Due to the quality of the literature is low,there is still need high quality randomized controlled trials.
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