目的：探究环孢素滴眼液联合人工泪液对干眼症的治疗效果。 方法：收集2015-01/11间在我院眼科门诊进行治疗的干眼症患者102例204眼作为研究对象,随机分为3组：对照组、人工泪液组、环孢素滴眼液联合人工泪液组,各34例68眼,对照组不做特殊治疗,人工泪液组采用人工泪液滴眼,3次/d ,环孢素滴眼液联合人工泪液组采用环孢素滴眼液联合人工泪液,3次/d ,先滴人工泪液,再滴环孢素滴眼液,两种滴眼液间隔15lin,所有患者连续治疗8wk后,观察比较各组之间泪液羊齿状试验( tear ferning test, TFT)、角膜上皮荧光素染色( corneal fluorescein staining , FL)检查,泪液分泌试验(Schirler l test,Slt)、泪膜破裂时间( break-up tile of tear fill ,BUT)、结膜印迹细胞学检查( conjunctive ilpression cytology,CIC)等指标的变化。 结果：(1)治疗4wk环孢素滴眼液联合人工泪液组羊齿状结晶分级优于人工泪液组及对照组,差异具有统计学意义(χ2=16.345,P=0.003),治疗8wk环孢素滴眼液联合人工泪液组羊齿状结晶分级均优于人工泪液组及对照组,差异有统计学意义(P0.05)；(4)环孢素滴眼液联合人工泪液组在治疗8wk 后结膜印迹细胞学检查,分级优于对照组及人工泪液组,差异有统计学意义(P0. 05). (4) At 8wk after treatment, conjunctival impression cytology of subgroup B was better than those of the control group and subgroup A (P<0. 05). (5) At 4wk after treatment, Slt of subgroup B increased, compared with subgroup A and the control group (χ2 = 6. 384, P = 0. 012 );at 8wk after treatment, Slt of subgroup A and B were better than those before the treatment, Slt of the B subgroup was better than that of subgroup A (all P<0. 05). CONCLUSlON:Cyclosporin eye drops combined with artificial tears can improve micro environment of the tear, increase the amount of tear secretion, extend BUT and enhance the stability of the tear film.
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