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首页> 外文期刊>The ocular surface >Efficacy and Safety of Topical 0.05% Cyclosporine Eye Drops in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-analysis
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Efficacy and Safety of Topical 0.05% Cyclosporine Eye Drops in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-analysis

机译：局部0.05％环孢素滴眼液治疗干眼症的疗效和安全性：系统评价和荟萃分析

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摘要

A systematic review was performed to evaluate the safety and efficacy of topical 0.05% cyclosporine in treating patients with dry eye syndrome (DES). Twelve qualified randomized-controlled trials incorporating 1367 patients were analyzed. In comparison to controls, patients who were on topical 0.05% cyclosporine eye drops had lower Ocular Surface Disease Index scores (mean difference [MD]=4.10, 95% CI: 0.25-7.96, P=.04), longer tear film breakup time (MD=2.30 seconds, 95% CI: 0.75-3.86, P=.004), improved Schirmer I scores (MD=2.77 mm/5min, 95% CI: 1.63-3.91, P=.00001), reduced corneal fluorescein staining (standardized mean difference [SMD]=0.61, 95% CI: 0.07-1.15, P=.03), and higher goblet cell densities (SMD=1.68, 95% CI: 0.54-2.81, P=.004). However, there were more adverse effects in the cyclosporine patient group (odds ratio = 1.64, 95% CI: 1.17-2.30, P=.004). Topical 0.05% cyclosporine eye drops twice daily significantly improved both the objective and subjective outcomes in DES patients. The study limitations in the clinical, methodological and statistical heterogeneities are discussed.
机译：进行了系统的评估，以评估局部用0.05％环孢素治疗干眼症（DES）患者的安全性和有效性。分析了十二项纳入1367名患者的随机对照试验。与对照组相比，使用局部0.05％环孢素滴眼液的患者眼表疾病指数评分较低（平均差异[MD] = 4.10，95％CI：0.25-7.96，P = .04），泪膜破裂时间更长（MD = 2.30秒，95％CI：0.75-3.86，P = .004），改善了Schirmer I评分（MD = 2.77 mm / 5min，95％CI：1.63-3.91，P = .00001），减少了角膜荧光素染色（标准化平均差异[SMD] = 0.61，95％CI：0.07-1.15，P = .03）和更高的杯状细胞密度（SMD = 1.68，95％CI：0.54-2.81，P = .004）。但是，环孢素患者组的不良反应更多（几率= 1.64，95％CI：1.17-2.30，P = .004）。每天两次局部用0.05％环孢素滴眼液可显着改善DES患者的客观和主观预后。讨论了临床，方法学和统计异质性方面的研究局限性。

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