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LIPOSOMIAL EYE DROPS SOLUTION AND USES THEREOF FOR THE TREATMENT OF DRY EYE SYNDROME
LIPOSOMIAL EYE DROPS SOLUTION AND USES THEREOF FOR THE TREATMENT OF DRY EYE SYNDROME
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机译：脂质眼滴溶液及其用途用于治疗干眼综合征
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摘要
- Ophthalmic formulations and uses thereof, for the treatment of dry eye syndrome, wherein an eye drops solution is composed of liposomes built with non hydrogenated phospholipids containing Linseed oil, Vitamin A Palmitate, Vitamin E TPGS and in water phase Vitamin B12 and Pycnogenol.- The presence of Pycnogenols increases the antioxidant capacity in external water phase and the presence of Vitamin E TPGS increases the antioxidant effect on lipophilic phase of liposomes.- The presence of Vitamin E TPGS, inside the liposomes, combined with the presence of Pycnogenol and Vitamin B12 outside the liposomes, have a protective effect (shield) against UV A/UVB rays.- It is further object of the invention, a liposomal eyes drops solution as above described, containing a specific and peculiar system composed of 2-Amino-2(hydroxymethyl) propane-1,3-diol, that act as salt forming agent for Pycnogenol (sparkly water soluble) and borate buffer, in order to improve the filterability of liposomes and have a satisfying filtration procedure to sterilize liposomial eyes drops only by filtration at 0.2 micron, avoiding the steam sterilization that would destroy the other components and liposomes structure.
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机译：- 用于治疗干眼综合征的眼科制剂及其用途，其中滴眼液溶液由含有含有亚麻籽油的非氢化磷脂，维生素A棕榈酸盐，维生素E TPG和水相维生素B12和Pycnognol的脂质体组成.-碧萝芷的存在增加了外部水相中的抗氧化能力，维生素E TPG的存在增加了对脂质体的亲脂相的抗氧化作用.-脂质体内部的维生素E TPG的存在，与碧萝芷和维生素B12的存在合并在脂质体外，对UV A / UVB射线具有保护作用（屏蔽）.-本发明的另一个目的是如上所述的脂质体眼睛滴加溶液，含有由2-amino-2组成的特异性和特殊的系统（羟甲基）丙烷-1,3-二醇，用作盐形成剂的盐形成剂（闪亮水溶性）和硼酸盐缓冲液，以提高脂质体的过滤性D具有令人满意的过滤程序，以消毒脂质体眼睛仅在0.2微米下过滤液滴，避免将破坏其他组分和脂质体结构的蒸汽灭菌。
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