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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome
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A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome

机译：透明质酸滴眼滴滴治疗干眼症综合征的荟萃分析

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Hyaluronic acid (HA) is commonly used for treating dry eye syndrome (DES). This meta-analysis was performed to compare the efficacies of HA- and non-HA-based eye drops, including saline and conventional artificial tears (ATs), for the treatment of dry eye disease. Eight databases (PubMed, EMBASE, Cochrane Central Register of Controlled Trials, DBpia, KoreaMed, KMBASE, RISS, KISS) were searched for studies comparing the efficacies of HA- and non-HA-based ATs in patients with DES published up to September 2020. Two independent reviewers assessed the quality and extracted the relevant data. The mean differences of Schirmer’s (SH) test scores, tear breakup times (TBUT), corneal fluorescein staining scores (Oxford scale, 0–4), and ocular surface disease indexes were calculated. The standard mean difference and 95% confidence interval were calculated using a random effect model. Nineteen studies, including 2078 cases, were included. HA eye drops significantly improved tear production compared with non-HA-based eye drops (standard mean difference (SMD) 0.18; 95% confidence interval (CI) 0.03, 0.33). In a subgroup analysis, the SH test scores and TBUT values after using HA significantly increased compared to those measured after using saline (SMD 0.27; 95% CI 0.05, 0.49 and SMD 0.28; 95% CI 0.03, 0.52, respectively). Based on these results, HA eye drops may be superior to non-HA eye drops including normal saline and ATs. Further research is needed to assess the efficacies stratified by age, treatment duration, the severity of dry eye, and optimal dosages.
机译：透明质酸（HA）通常用于治疗干眼综合征（DES）。进行该META分析以比较HA-和非HA型眼滴的疗效，包括盐水和常规人工泪（ATS），用于治疗干眼症。八个数据库（受控试验，DBPIA，Koreamed，KMBase，Riss，Kiss的PubMed，Embase，Cochrane中央登记册）被搜查了学习比较了HA-和非HA基ATS患者在2020年9月发布的患者中的疗效。两个独立审稿人评估了质量并提取了相关数据。计算了沉壮（SH）测试评分，撕裂分段（TBUT），角膜荧光素染色评分（牛津量表，0-4）和眼表面疾病指标的平均差异。使用随机效应模型计算标准平均差异和95％置信区间。包括2078例，包括2078例。与非HA型眼滴相比，HA EYE下降显着改善撕裂生产（标准平均差异（SMD）0.18; 95％置信区间（CI）0.03,0.33）。在亚组分析中，与使用盐水后测量的人相比，使用HA后的SH测试分数和结核病值（SMD 0.27; 95％CI 0.05,0.49和SMD 0.28; 95％CI 0.03,0.52）。基于这些结果，HA滴滴涕可能优于非HA滴眼液，包括生理盐水和ATS。需要进一步研究来评估年龄，治疗持续时间，干眼症严重程度和最佳剂量分层的疗效。

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