RANDOMIZED TRIAL COMPARING THE EFFECT OF BRIMONIDINE AND TIMOLOL ON VISUAL FIELD LOSS AFTER ACUTE PRIMARY ANGLE CLOSURE

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RANDOMIZED TRIAL COMPARING THE EFFECT OF BRIMONIDINE AND TIMOLOL ON VISUAL FIELD LOSS AFTER ACUTE PRIMARY ANGLE CLOSURE

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《国际眼科杂志》 |2003年第1期|77-78|共2页
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Tan Tock Seng Hospital;

Singapore National Eye Centre;

Singapore National Eye Centre;

Clinical Trails & Epidemiology Unit;

Tan Tock Seng Hospital;

Clinical Trails & Epidemiology Unit;

Singapore National Eye Centre;

National University Hospital;

Singapore;

Singapore National Eye Centre;

National University Hospital;

Singapore;

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原文格式 PDF
正文语种 chi
中图分类眼科学;
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5. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
6. Impact of micronutrient supplementation during pregnancy on birthweight，duration of gestation and perinatal mortality in rural western China：double-blind cluster randomized controlled trial [C] . Lingxia Zeng ,Michael J．Dibley ,Yue Cheng . 2007年中国卫生统计学术大会 . 2007
7. Effect of IOC2 index monitoring on remifentanil dosage during desflurane anesthesia:a randomized trial [A] . Nirajan Mahaseth . 2017

RANDOMIZED TRIAL COMPARING THE EFFECT OF BRIMONIDINE AND TIMOLOL ON VISUAL FIELD LOSS AFTER ACUTE PRIMARY ANGLE CLOSURE

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