Amino acids have been pointed out as potent stimulators of growth hormone (GH) secretion. Among them, L-arginine is considered one of the most effective GH releasers. L-arginine increases GH release in pituitary when given orallyor intravenously. L-arginine-stimulated GH secretion can be mediated by several signaling systems, but nitric oxide (NO) dependent soluble guanylyl cyclase (sGC) -cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) pathway plays a key role in the process of L-arginine-stimulated GH secretion.%氨基酸是促进垂体生长激素(GH)分泌的潜在刺激因子.在所有氨基酸中,左旋精氨酸(L-精氨酸)促GH分泌作用最为明显.口服或静脉滴注精氨酸均可刺激垂体GH的分泌.L-精氨酸促GH的分泌可能涉及多种机制,但一氧化氮(NO)依赖的可溶性鸟苷酸环化酶-环鸟苷酸-蛋白激酶G(sGC-cGMP-PKG)信号转导通路在此过程中起着重要作用.
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