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《国际肝胆胰疾病杂志（英文版）》
>Transplantation Expression of 4-1BB molecule on peripheral blood T cells in liver transplanted patients and its clinical implication
Transplantation Expression of 4-1BB molecule on peripheral blood T cells in liver transplanted patients and its clinical implication
OBJECTIVE: To investigate the gene expression of 4-1BB in peripheral blood mononuclear cells(PBMCs) and its possible significance in clinical liver transplantation.METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the geneexpression of 4-1BB in PBMCs from 22 patients receiving liver transplantation, 13 patients with primaryliver carcinoma (PLC), and 12 healthy controls. To determine whether 4-1BB molecule is also expressedon the surface of CD4^+ and CD8^+ T cell, flow cytometry was used to analyse the phenotype of T cellsubsets from the blood of liver transplantation patients.RESULTS: 4-1BB mRNA was detected in PBMCs from stable survivors after liver transplantation, butalmost not deteeted in PBMCs from PLC patients and healthy controls. Meanwhile, 4-1BB was almost notexpressed on the surface of CD4^+ and CD8^+ T cells in healthy controls and PLC patients. A low level of4-1BB expression, however, was found on the surface of CD4^+ and CD8^+ T cells from the stablesurvivors after liver transplantation.CONCLUSIONS: This study demonstrates that although patients are stable after liver transplantation,effector T-cells can also be activated through the signal of 4-1BB molecule and persistent irmmune responseto grafts. Blockage of 4-1BB/4-1BBL pathway may benefitially reduce the clinical dosage ofimmunosuppressive agents and prolong the survival of grafts.
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机译：Clinical Manifestation, Distribution and Resistance of Pathogen Causing Bacteremias Following Solid Organ Transplantation: A Clinical Analysis of 149 PatientsAU Liu, Jia Shao, Mingjie Wan, Qiquan (13548685542@163.com) Ye, Qifa Zhou, Jiandang
机译：Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment
