There is great concern for the increasing incidence of hyperuricemia (HUA). HUA is not only the main cause of gout, but also closely related to many systemic diseases and their development such as kidney diseases and cardiovascular diseases. This article briefly describes the metabolism of serum uric acid (SUA) and the biological effects of antioxidants, as well as the mechanism of kidney injury induced by HUA.%高尿酸血症(hyperuricemia,HUA)逐年升高的发病率使其受到人们广泛的关注.HUA不仅是痛风的主要原因,它还与肾、心血管等多系统性疾病的发病及发展密切相关.本文简要介绍血清尿酸(serum uric acid,SUA)的代谢及抗氧化剂的生理学作用、HUA致肾损伤的机制.
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