Nanog is a transcription factor that is involved in the self-renewal of embryonic stem cells (ES) and is a critical factor for the maintenance of the undifferentiated state of pluripotent cells. Extensive data in the literature show that the Nanog gene is aberrantly expressed during the development of malignancy in cancer cells. Nanog is specifically involved in the process of carcinogenesis and can be a potential biological and prognostic marker for malignant tumors.%Nanog是一个参与胚胎干细胞自我更新的转录因子,在多能细胞保持未分化状态的维持中起关键性作用.越来越多的资料表明Nanog基因在肿瘤细胞恶性表型的发展过程中异常高表达.Nanog特异性参与肿瘤的发生过程,是一种潜在的恶性肿瘤生物学和预后的标志物.
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