Mitochondrionisan eukaryotic organelle that generatesmore than 90%of the energy in the cell by oxidative phosphorylation (OXPHOS). Mitochondrial dysfunction is an important pathophysiological mechanism for many common disorders, associated with impairing of OXPHOS and increasing reactive oxidative species (ROS) production. In this review we will discuss production of ROS caused by mitochondrion, affected factors and multiple effects on the tissue and cells.%线粒体是重要的真核细胞的细胞器，通过氧化磷酸化为细胞提供90%以上能量。线粒体功能紊乱与氧化磷酸化功能损害和活性氧产生增多密切相关，是导致多种疾病的重要的病理基础。本文将针对线粒体产生活性氧的方式、影响因素以及活性氧对机体组织及细胞的影响进行阐述。
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