[目的]研究内皮素在甲亢和正常母鼠心脏中的差异表达.[方法]首先建立妊娠合并甲亢模型,观察大鼠的行为变化、体重变化,检测甲功水平；然后对孕16、18、20d母鼠和出生5、10、15 d母鼠心脏,免疫组化检测内皮素的差异表达.[结果]甲亢合并妊娠组大鼠心肌中的内皮素表达高于对照组,并且甲亢组心肌中的内皮素随着受孕时间的延长而加剧,在产后也随时间的延长而加剧.[结论]该研究可为探讨妊娠合并甲亢对心脏的损伤情况奠定基础.%[Objective]To study the differential expression of endothelin on hearts between the hyperthyroidism and normal rats in perinatal stage. [Method] First set up the model of hyperthyroidism with pregnancy, observing the change of behavior and weight, detecting hyperthyroidism level; Then get the hearts of 16th day, 18th day, 20th day after gestation and 5th day, 10th day, 15th day after parturition, detecting the expression of endothelin through immunohistochemistry. [ Result] The expression of endothelin in hyperthyroidism rats are more than the normal ones in the perinatal age. Moreover this change increased with time prolonged. [ Conclusion] The study will lay a foundation for discussing the harmful effects of hyperthyroidism with pregnancy on hearts.
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