[目的]研究人参三七提取物缓解体力疲劳的作用,为进一步开发利用人参三七提供试验依据.[方法]将小鼠分为4批,每批48只,随机分为4组,分别为对照组和50、100、300 mg/kg 3个给药组,各组小鼠经口灌胃给药30 d后,分别测定其负重游泳时间及血清尿素氮、血乳酸、肝糖原含量.[结果]100和300 mg/kg 剂量组人参三七提取物小鼠负重游泳时间显著长于对照组(P<0.01),血清中尿素氮含量显著低于对照组(P<0.01;P<0.05),小鼠肝糖原水平明显高于对照组(P<0.01;P<0.05);小鼠游泳后血乳酸含量显著低于对照组(P<0.01;P<0.05).[结论]人参三七提取物具有缓解体力疲劳的作用.%[ Objective] To explore the anti-fatigue effect of RADIX ET RHIZOMA GINSENG and RADIX NOTOGINSENG extracts in mice,so as to provide reference for further development and application of RADIX ET RHIZOMA GINSENG and RADIX NOTOGINSENG extracts.[ Method] Divided into four batches, forty-eight mice in each batch were subdivided into four groups like control group (CK), 50, 100 and 300 mg/kg medicine group. The loaded swimming duration and content of serum urea nitrogen, blood lactate and hepatic glycogen of mice in each test group were determined respectively 30 days later. [ Result] In comparison with control group, mice in the group of 100 and 300 mg/kg medicine group were significantly longer in loaded swimming duration ( P ＜ 0.01 ), and higher in content of hepatic glycogen ( P ＜ 0. 01; P ＜0.05 ), whereas was lower in content of serum urea nitrogen (P ＜ 0.01; P ＜ 0.05 ). Contents of blood lactate in mice in 100 and 300 mg/kg medicine group after exercise were significantly lower than those in control group( P ＜0.01 ;P ＜0.05 ). [ Conclusion] RADIX ET RHIZOMA GINSENG and RADIX NOTOGINSENG extracts are provided with efficacy of alleviating physical fatigue.
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