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首页> 外文期刊>Chinese Medicine >Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells
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Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells

机译：三七提取物和人参提取物及其人参皂苷成分对人肝癌细胞的抗增殖作用

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Background Panax notoginseng is a potential source of anticancer compounds. This study aims to investigate the effects of steaming on the chemical profile of P. notoginseng and the anti-proliferative effects of P. notoginseng on liver cancer cells. Methods Samples of powdered raw P. notoginseng roots were steamed for various durations. Extracts of the raw and steamed samples were subjected to ultra-high pressure liquid chromatography/mass spectrometry (UHPLC-MS) analysis for chemical profiling. The anti-proliferative effects on three human liver cancer cells, namely SNU449, SNU182 and HepG2, were evaluated using colorimetric WST-1 assay. Results Steaming changed chromatographic and pharmacological profiles of P. notoginseng, causing differences in activities such as inhibition of cancer growth. Steamed P. notoginseng exhibited greater anti-proliferative effects against liver cancer cells (SNU449, SNU182 and HepG2) than its raw form; steaming up to 24 hours increased bioactivities. Steaming increased the concentrations of ginsenoside Rh2, Rk1, Rk3 and 20S-Rg3 and enhanced growth inhibition of liver cancer cells. Conclusion Steaming changes the chemical profile as well as anti-cancer biological activities of P. notoginseng. Steamed P. notoginseng contains potential compounds for the treatment of liver cancer.
机译：背景三七是潜在的抗癌化合物来源。这项研究旨在调查蒸煮对三七的化学特性的影响以及三七对肝癌细胞的抗增殖作用。方法将生三七粉的生根粉样品蒸制不同的时间。对原始和蒸煮样品的提取物进行超高压液相色谱/质谱（UHPLC-MS）分析，以进行化学分析。使用比色WST-1分析评估了对三种人类肝癌细胞SNU449，SNU182和HepG2的抗增殖作用。结果蒸煮改变了三七的色谱和药理特性，从而导致了活性的差异，例如抑制了癌症的生长。蒸过的三七对生肝癌细胞（SNU449，SNU182和HepG2）的抗增殖作用比其原始形式要大。蒸多达24小时可提高生物活性。蒸煮增加人参皂苷Rh 2 ，Rk 1 ，Rk 3 和20S-Rg 3 的浓度并增强生长抑制肝癌细胞。结论蒸煮可改变三七的化学特性和抗癌生物学活性。蒸三七含有潜在的化合物，可治疗肝癌。

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