[目的]研究自制的利福昔明杂质A和杂质B与刹福昔明在不同条件下的变化规律.[方法]在酸、碱、氧化、高温的条件下,采用高效液相色谱法测定利福昔明及其有关物质含量.[结果]在1 mol/L HCI和1 mol/L NaOH溶液条件下,杂质A和杂质B均不稳定,在1 ml双氧水的条件下,杂质A非常稳定,而杂质B不稳定.杂质B在100℃下可部分转化为杂质A.[结论]在较高温度下,杂质B可部分转化为杂质A,在酸、碱条件下杂质A和杂质B均不稳定.%[ Objective ] To study the variation of the rifaximin and the two prepared impurities in different conditions. [ Method ] The contents and related substances of the two unknown impurities were determined by RP-HPLC method in the condition of acid, alkali, oxidation and high temperature. [ Result ] The two impurities were found very unstable in acid and alkali as 1 M hydrochloric acid and 1M sodium hydroxide soltion. But the impurity A was found very stable in the 1M hydrogen peroxide solution, nor the impurity B. And the impurity B was found converted to the impurity A in the 100 centigrade partial. [ Conclusion ] The two unknown impurities were found very unstable in the acid and alkali condition. But the impurity B can be converted into the impurity A partial in the high temperature condition.
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