Aiming at many problems in process of experiment teaching of microcomputer principles and interface technique , this paper discusses the idea of experiment teaching based on Proteus simulation.Taking the simulating of peripheral interface 8255A as an example, we illustrate the basic process of Proteus simulation.The practice proves that the method can not only over-come the disadvantages of the fixed hardware experiment instruments and limited resources , but also deepen the students'compre-hension of curriculum knowledge and mobilize the students'enthusiasm to study, and enhance the effect of experiment teaching fur-ther.%针对《微机原理与接口技术》实验教学的诸多问题，阐述了通过 Proteus仿真软件进行实验教学的新思路。以并行接口芯片8255 A的仿真实例，说明了Proteus实验仿真的基本过程。实践表明，基于Proteus实验仿真方法不仅能够克服硬件实验箱结构固定、资源有限等缺点，还能加深学生对课程知识点的理解和调动学习积极性，从而进一步提高实验教学效果。
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