目的:系统评价慢性乙型肝炎(CHB)患者外周血T淋巴细胞(TC细胞)亚群的变化情况及与乙型肝炎病毒脱氧核糖核酸(HBV-DNA)的关系.方法:通过计算机检索2000年1月1日至2013年12月31日公开发表于Medline(检索平台PubMed)、Embase(检索平台Ovild)、Central(检索平台Ovild)、维普、万方、知网等数据库所有关于CHB患者外周血TC细胞亚群变化的相关中英文文献.由2位评价人员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用RevMan 5.3软件进行Meta分析.结果:CHB患者外周血CD3+、CD4+T细胞和CD4+/CD8+比值均低于健康人群(P0.05).HBV-DNA阳性组与HBV-DNA阴性组比较,外周血CD3+、CD4+T细胞百分率和CD4+/CD8+均显著降低(P0.05).结论:CHB可导致人体外周血TC细胞亚群的改变,其变化与HBV-DNA含量呈相关性.%Objective:To analyze the T-lymphocyte subsets change in peripheral blood of patients with chronic hepatitis B( CHB) ,and its correlation with hepatitis B-deoxyribonucleic acid( HBV-DNA) . Methods:The relative literatures of T-lymphocyte subsets change in peripheral blood of patients with CHB from Medline ( PubMed retrieval platform ) , Embase ( Ovild retrieve platform ) , Central ( Ovild retrieval platform),Whip,Wanfang and CNKI from January 1,2000 to December 31,2013 were searched. Independent screening documents,extracting information and evaluation were implemented independently by 2 evaluators according to the inclusion and exclusion criteria,which was analyzed by Meta using RevMan 5. 3 software. Results:The percentage of CD3 +T,CD4 +T and CD4 + T/CD8 + T in patients with CHB were lower than those in healthy people,but the percentage of CD8 +T cells of patients was higher( P0. 05). Compared with the negative HBV DNA patients,the percentage of CD3 +T,CD4 + T and CD4 +T/CD8 +T, and percentage of CD8 + T decreased and increased significantly in the positive HBV DNA patients, respectively ( P 0. 05). Conclusions:HBV infection can lead to the change of T cell subsets of patients,which is positively related to the HBV-DNA level.
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