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首页> 中文期刊> 《质谱学报》 >电喷雾萃取电离-四极杆飞行时间质谱快速分析一次性注射器中的挥发性有机物残留

电喷雾萃取电离-四极杆飞行时间质谱快速分析一次性注射器中的挥发性有机物残留

         
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摘要

Residual volatiles in disposable syringe can be injected into human body, which is considered as a potential health risk.Traditional method like gas chromatogra-phy (GC) , liquid chromatography (LC) and gas chromatography-mass spectrometry (GC/MS) are relative time consuming for detection .In this study ,extractive electrospray ionization quadrupole time of flight mass spectrometry (EESI-Q TOF MS) was used for rapid analysis of volatiles in disposable syringe . The EESI ion source allows direct sampling of mixture ,while the Q TOF promises an accurate measurement of m/z value as a high resolution mass spectrometry . The mass spectra were recorded in the mass range of m/z 20-200 in positive ion mode .To assist identification of compounds ,collision induced dissociation (CID) analysis was performed with collision energy of (20 ± 10) eV .Analytes were sampled via a T-tube ,and sucked into the source chamber from the bypass through an 80 cm long ,1.5 mm inner-diameter PTEF tube .The PTFE tube was heated to a constant temperature of 100 ℃ to avoid condensation which may lead to compound losses .The curtain gas was set at 4.0 L/min and 200 ℃ .Ion source parameters were optimized using cyclohexanone ,and the optimal sampling flow rate and capillary voltage were set at 3.5 L/min and 4 000 V , respectively . Various volatiles were detected from 9 syringes in 10 mL with 3 brands . Results showed that volatile compounds are similar in syringes with the same brands ,but significantly different in species and content for syringes with different brands .Based on CID analysis ,a total of 10 compounds with intensity over 5 000 are identified including dimethylformamide (m/z 74.060 2 ) , dimethyl sulfoxide (m/z 79.021 1 ) , morpholine (m/z 88.076 5 ) ,cyclohexanone (m/z 99.080 2 ) ,ethylbenzene (m/z 107.085 9 ) ,4-vinyl-1-cyclohexene (m/z 109.101 6) ,diethyl urea (m/z 117.102 8) ,4-methyl-4-vinyl-1 ,4-butanolide (m/z 127.075 6) ,benzothiazole (m/z 136.021 9 ) and dibutylformamide (m/z 158.154 5 ) .According to previous studies ,some of these volatile compounds are toxic and harmful to human body .Detection of syringes in different capacity including 10 mL ,20 mL and 50 mL were also performed .And the result showed that syringes in larger volume would cause more residual volatiles .To estimate the content of residual volatiles ,semi-quantitative analysis of cyclohexanone was carried out ,and the limit of detection (LOD) is calculated to be 0.13 μg/L .Concentration of cyclohexanone in 10 mL syringe ranges from 0.39 to 0.64 μg/L .Maximum concentration of 2.52 μg/L is detected in 50 mL syringe .This study provides an effective way for rapid analysis of volatiles ,and shows great potential in quality control of disposable syringe .%一次性医用注射器中残留的有机物会通过注射药物进入人体,对健康构成危害.本研究利用电喷雾萃取电离-四极杆飞行时间质谱仪(EESI-Q TOF MS)快速检测和分析一次性注射器中的挥发性有机物残留.通过优化载气流量和毛细管电压,确定了最佳实验条件.在3种不同品牌的10 mL一次性医用注射器中检测到多种挥发性物质.选取10个信号强度大于5000的离子,利用碰撞诱导解离进行定性分析.对注射器中残留的环己酮进行半定量分析,检出限为0.13 μg/L.实验还发现,环己酮在不同品牌的10 mL注射器中的含量为0.39~0.64 μg/L,在50 mL注射器中的最大残留浓度达到2.52 μg/L.结果表明,注射器体积越大,有机物残留量越高.该研究可为一次性注射器有机物残留检测和质量控制提供快速有效的技术手段.

著录项

  • 来源
    《质谱学报》 |2018年第1期|93-100|共8页
  • 作者

    周文钊; 陆燕; 夏磊; 黄超群; 沈成银; 储焰南;

  • 作者单位

    中国科学院合肥物质科学研究院,医学物理与技术中心,医学物理与技术安徽省重点实验室,安徽 合肥 230031;

    中国科学技术大学,安徽 合肥 230026;

    中国科学院合肥物质科学研究院,医学物理与技术中心,医学物理与技术安徽省重点实验室,安徽 合肥 230031;

    中国科学院合肥物质科学研究院,医学物理与技术中心,医学物理与技术安徽省重点实验室,安徽 合肥 230031;

    中国科学院合肥物质科学研究院,医学物理与技术中心,医学物理与技术安徽省重点实验室,安徽 合肥 230031;

    中国科学院合肥物质科学研究院,医学物理与技术中心,医学物理与技术安徽省重点实验室,安徽 合肥 230031;

    中国科学院合肥物质科学研究院,医学物理与技术中心,医学物理与技术安徽省重点实验室,安徽 合肥 230031;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 质谱分析;
  • 关键词

    一次性注射器; 挥发性有机物; 电喷雾萃取电离质谱;

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