Panax ginseng C .A .Mey (ginseng) is a traditional Chinese medicine herb , w hich has been widely used for the treatment of enhancing intelligence and improving immunity in China and Aisa .As a new resource food in China ,ginseng has a variety of processing methods which are used for different symptoms .The major active compo‐nents of ginseng are ginsenosides ,w hich demonstrate the ability to target a number of tissues and produce an array of pharmacological responses .In this study ,active compo‐nents from mud‐covered processed‐ginseng were studied whether the chemical composi‐tion of ginseng is safety and reliable .Rapid resolution liquid chromatography coupled with quadrupole‐time‐of‐flight tandem mass spectrometry (RRLC‐Q‐TOF MS/MS) was used to compare the white ginseng ,vinegar processed ginseng and mud‐covered pro‐cessed ginseng for the composition of ginsenosides .Chromatographic conditions were as follow s :ZORBAX SB‐C18 column (2.1 mm × 100 mm × 3.5 μm ) ,column temperature of 35 ℃ ,mobile phase of water‐acetonitrile gradient elution ,flow rate of 0.3 mL/min , injection volume of 5 μL .Thirty‐one ginsenosides were identified by the comparison of the retention times of the standard compounds and the accurate mass obtained from RRLC‐Q‐TOF MS/MS .A few minor ginsenosides ,such as ginsenoside F2 and Rg3 , were detected by the comparison of white ginseng with processed‐ginseng .The method is applicable to the research of compounds in the processed Chinese herbs .%人参作为新资源食品，有多种炮制方法的应用。本研究对于黄泥煨制的人参化学成分是否安全、可靠提供了借鉴。利用高分离度快速液相色谱‐四极杆‐飞行时间质谱（RRLC‐Q‐TOF MS）法研究黄泥煨炮制方法的人参化学成分。鲜人参黄泥煨制的样品溶解离心过滤后，采用 Agilent ZORBAX SB‐C18色谱柱，以0.1％甲酸水‐乙腈溶液作为流动相进行梯度洗脱，高分辨质谱进行检测，Masshunter Qualita‐tive Analysis软件与人工相结合进行数据分析。结果表明，本研究鉴定了31种人参皂苷，比较了黄泥煨制人参与其他炮制方法人参中人参皂苷的相对百分含量差异，同时检测到F2、Rg3等稀有人参皂苷。该研究可为人参的使用提供更多的途径，能够为开发人参的多种保健功能提供依据。
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