MicroRNA-137(miR-137)异常表达与多种肿瘤的发生发展密切相关,miR-137启动子区域甲基化改变是使其异常表达的重要机制之一.其甲基化改变的程度在多种肿瘤中明显增高,但发生甲基化改变的频率在不同肿瘤中明显不同,也在不同肿瘤中与不同的临床病理特征相关,此外,发生甲基化改变的肿瘤患者预后更差.miR-137启动子区域甲基化改变可促进肿瘤发生发展,并具有在早期能被检测、高特异性等特点,表明有作为肿瘤标记物的潜能,且逆转其甲基化改变亦可为肿瘤治疗提供新的策略及突破口.%The aberrant expression of MicroRNA-137 (miR-137) is correlated with different tumors closely,miR-137 promoter methylation considered as one of the most important mechanisms through which miR-137 expression can be regulated.The degree of promoter methylation of miR-137 was significantly increased in tumors,but the frequencies varied.In addition,it correlated with different clinical and pathological characteristics in tumors.Furthermore,miR-137 promoter methylation indicated poor prognosis.miR-137 promoter methylation promoted the initiation and progression of tumors,it was of potential to be a biomarker and reversed the methylation status of miR-137 represented a novel strategy of cancer treatment.
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