目的：观察药物联合紫外线照射治疗老年寻常型银屑病的疗效及对免疫炎症指标的影响。方法分析2011年1月至2013年1月接受治疗的85例银屑病患者的临床资料，随机将患者分为两组。观察组45例采用药物联合紫外线治疗，对照组40例仅采用药物治疗。比较两组患者的治疗效果及血液炎症指标[ C 反应蛋白（ CRP）、血管内皮生长因子（VEGF）、单核细胞趋化蛋白4（MCP -4）及外周血骨桥蛋白（OPN）]。结果治疗8周后，观察组总体治疗有效率显著高于对照组（ P <0.05）。治疗第4、6、8周时观察组银屑病皮损面积和严重程度指数（ PASI）评分显著低于对照组（ P <0.05）。治疗后4、6及8周，观察组受损皮肤面积均显著低于对照组，差异均具有统计学意义（ P <0.05）。治疗后8周，观察组 MCP -4、VEGF、CRP 和 OPN 水平均显著低于对照组（ P <0.001）。结论老年寻常型银屑病的治疗中，加入紫外线照射治疗可以显著提高疗效，其机制可能与紫外线照射减轻了皮损处免疫炎症反应有关。%Objective Our study was aimed to analyze the curative effect of Ultraviolet ray combined with medicine in the treatment of psoriasis. Methods Clinical data of patients with psoriasis received treatment at our hospital from 2011 to 2013 was analyzed. Patients were di-vided into two groups by therapeutic methods. Group A:received the treatment of ultraviolet ray combined with medicine. Group B received medi-cine. Results A total of 85 patients were analyzed,Group A 45,Group B 40. After 8 weeks treatment,Group A patients had a higher response rate than that of Group. The difference was statistically significant( P < 0. 05). Group A patients had lower PASI scores and damaged skin areas than these of Group B( P < 0. 05)during week 4,6 and 8. After 8 weeks treatment,Group A had lower levels of MCP - 4,VEGF,CRP and OPN than these of Group B( P < 0. 05). Conclusion In the treatment of psoriasis,the curative effect of Ultraviolet ray combined with medicine was better than medicine only,and this may result from reducing levels of inflammatory factors by ultraviolet ray.
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