目的：对比分析去甲肾上腺素与垂体后叶素治疗感染性休克的临床疗效。方法80例感染性休克患者随机分为两组，研究组在常规治疗基础上应用垂体后叶素，对照组在常规治疗基础上应用去甲肾上腺素治疗，比较两组治疗后复苏成功率、多器官功能障碍综合征发生率、机械通气支持时间、ICU 住院时间和血乳酸水平变化等。结果研究组患者治疗后血乳酸水平均显著低于对照组；研究组患者6 h 内复苏成功率为85.0%，高于对照组（52.5%），多器官功能障碍综合征发生率为22.5%，低于对照组（47.5%），差异均有统计学意义（ P <0.05）。研究组机械通气支持时间和 ICU 住院时间均短于对照组，差异均有统计学意义（ P <0.05）。结论垂体后叶素治疗感染性休克临床效果优于去甲肾上腺素，其可有效改善组织缺氧状态，同时其还可缩短患者机械通气支持的时间，并促进患者早期康复出院。%Objective To compare and analyze the clinical efficacy of norepinephrine and pituitrin in the treatment of infectious shock. Methods 80 selected patients were randomly divided into two groups. The study group was given pituitrin based on conventional therapy. The control group was given norepinephrine based on conventional therapy. The changes of blood lactic acid(BLA)level of two groups after treatment were compared. Results After treatment,the BLA level of study group was significantly lower than that of control group. Resuscitation successful rate within 6h of study group(85. 0% )was higher than that of control group(52. 5% ). The MODS incidence of study group was 22. 5% ,which was lower than control group(47. 5% ). The differences between two groups were statistically significant( P ﹤ 0. 05). The mechanical ventilation support time and the hospital stays in ICU in study group were shorter than control group. The differences between two groups were statistically sig-nificant( P ﹤ 0. 05). Conclusion The clinical efficacy of pituitrin is better than norepinephrine in the treatment of infectious shock. It can im-prove the histanoxia status,shorten the mechanical ventilation support time,help patients recover soon.
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