Objective To explore the significance of AKIN staging criteria in early diagnosis and prognosis of patients with acute kidney injury caused by serious infection. Methods Sixty-eight patients with acute kidney injury caused by serious infections treated in the Department of Intensive Care of this hospital during August 2010 to December 2013 were selected for this study. They were divided into acute kidney injury stage I,stage II and stage III according to AKIN staging criteria. Patients in each group were treated with appropriate therapy according to AKIN staging criteria and clinical symptoms,they were given with continuous renal replacement therapy when necessary. Results According to AKIN staging,RIFLE classification standards and clinical symptoms in patients,the serum level of creatinine after appropriate treatment had significantly been reduced,and the level of creatinine was increased following the raise of AKIN staging. Patients with relatively high AKIN staging,the lower would be the cure rate and higher mortality rate,and the difference was statistically significant( P <0. 05). Conclusion Early diagnosis value of AKIN staging criteria is beneficial to the early diagnosis of acute kidney injury in patients caused by serious infection,and it is affirmative and effective in treatment of patients with early diagnosis,hence their prognosis will be good.%目的：探究急性肾损伤国际标准（ AKIN）分期标准对严重感染致急性肾损伤患者早期诊断及预后价值。方法选取2010年8月至2013年12月期间就诊的68例严重感染导致的急性肾损伤住院患者，按AKIN分期标准将急性肾损伤患者分为急性肾损伤Ⅰ期、Ⅱ期、Ⅲ期。每组患者根据AKIN分期标准、RIFLE分级标准以及临床症状采取相应疗法，必要时行连续性肾脏替代疗法。观察不同分期急性肾损伤患者血肌酐水平和临床疗效情况。结果根据A-KIN分期标准、RIFLE分级标准以及临床症状采取相应疗法后患者的血清肌酐水平均有明显降低，且随着AKIN分期升高，肌酐水平越高。而且三期患者的治疗情况比较，AKIN分期升高，治愈率越低，病死率越高，差异均有统计学有意义（ P <0.05）。结论 AKIN分期标准有助于早期诊断严重感染致急性肾损伤患者，而且对于早期患者的治疗效果显著，预后良好。
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