Objective To investigate the early changes in hemorheological parameters and thromboxane A2 (TXA2 )and prostacyclin (PGI2 )levels among patients with severe acute pancreatitis (SAP).Methods Thirty-two SAP patients hospitalized from January 2012 to September 2013 were selected as SAP group;30 healthy controls were selected as normal control (NC)group.Venous blood was collected after admission and before treatment.The hemorheological parameters and plasma levels of TXA2 and PGI2 were determined,and TXA2/PGI2 ratio was calculated.Comparison between groups was made by t test.Results Compared with the NC group,the SAP group had a sig-nificantly lower erythrocyte deformation index (t=2.185,P <0.05),significantly higher whole blood viscosities at high-,middle-,and low-shear rates and plasma viscosity (t=2.820,2.755,2.700,and 3.622,P<0.05),significantly higher whole blood reduced viscosi-ties at high-and low-shear rates (t=3.391 and 2.018,P<0.05),a significantly higher hematocrit (t=2.980,P<0.05),a signifi-cantly higher erythrocyte rigidity index (t=2.209,P<0.05),a significantly higher erythrocyte aggregation index (t=2.004,P<0.05), a significantly higher whole blood relative index at high shear rate (t=2.630,P<0.05),a significantly higher whole blood relative index at low shear rate (t=2.440,P<0.05),a significantly higher TXA2 level (t=3.256,P<0.05),a significantly higher PGI2 level (t=2.589,P<0.05),and a significantly higher TXA2/PGI2 ratio (t=2.640,P<0.05).Conclusion Hemorheological disorders and in-creased activity of vascular endothelial cells appear in the early stage in SAP.%目的：观察重症急性胰腺炎（SAP）患者早期血液流变学指标及血栓素A2（TXA2）、前列环素I2（PGI2）的变化。方法2012年1月至2013年9月住院的32例SAP患者为SAP组，30例体检健康人为NC组。于患者入院后治疗前即静脉采血，平行检测血液流变学指标及血浆TXA2、PGI2水平，并计算TXA2、PGI2比值。结果比较进行t检验。结果 SAP组血液流变学中除红细胞变形指数低于NC组（t＝2．185，P＜0．05）外，全血高、中、低切黏度、血浆黏度高于NC 组（t＝2．820、2．755、2．700、3．622，P＜0.05），全血高切还原黏度、全血低切还原黏度高于NC组（t＝3．391、2．018，P＜0．05），红细胞压积、红细胞刚性指数、红细胞聚集指数高于NC组（t＝2．980、2.209、2.004，P＜0．05）、全血高切相对指数、全血低切相对指数高于NC组（t＝2.630、2．440，P＜0．05）；SAP组TXA2、PGI2、TXA2、PGI2比值高于NC组（t＝3．256、2.589、2.640，P＜0．05）。结论 SAP患者早期即存在血液流变性异常及血管内皮细胞活性增高。
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