Liver cirrhosis is the end stage of various chronic liver diseases.Early diagnosis and staging of liver cirrhosis,as well as effective disease assessment,are of great clinical significance.The application of liver biopsy,serological testing,and radiological examination in the clinical diagnosis of liver cirrhosis and the research advances in evaluation of liver reserve function,complications,and prognosis are re-viewed.It is pointed out that with the development of molecular biological and imaging techniques,the accuracy and specificity of noninva-sive diagnosis will be increased,and the disease assessment system will be improved.%肝硬化是各种慢性肝病的终末阶段，如何早期诊断肝硬化及对肝硬化进行分期并进行有效病情评估，在临床工作中尤为重要。介绍了肝脏穿刺病理学检查、血清学检查及影像学检查在肝硬化的临床诊断中的应用，以及肝脏储备功能评估、并发症评估和预后评估的研究进展。指出随着分子生物学及影像学诊断技术的发展，必将大力提高无创诊断的准确性和特异性，并深入完善疾病的评估体系。
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