Objective To analyze the positive incidence and clinical significance of autoantibodies in the serum of patients with chronic hepatitis C in Tianjin. Methods 98 HCV patients were included in this study. The liver specific autoantibodies (ANA, ASA,AMA, RF, LKM-I) were detected by indirect immunofluorescence assay. The factors such as age, gender, and HCV replication were compared between the patients with positive and negative autoantibodies. Results Autoantibodies were detected in 32 individuals (at least one of them was positive), with the positive rate of 32.7％. The positive rate of ANA、 RF、 AMA、 LC-1 and LKM-l was 26.5％, 8.1％, 2.0％, 1.0％ and 1.0％ respectively. Compared with the autoantibody-negative patients, the factors related to the presence of autoantibody-positive were older age (57.1 vs 46.8), gender (female vs male 65.6％ vs 47.0％), worsening liver function, immune dysfunction and higher viral replication. Conclusion Autoimmune reactions exist in HCV patients. HCV infection can induce the production of many autoantibodies. The rate of positive autoantibodies is related to the age and HCV replication. Autoantibody may be an important factor in inducing hepatic injury after HCV infection.%目的 分析天津地区慢性丙型肝炎(CHC)患者血清中自身抗体阳性率及其临床意义.方法 选择天津地区98例CHC患者,检测自身抗体(ANA、ASA、AMA、RF、LKM-1)阳性率,并比较自身抗体(+)及自身抗体(-)群年龄、性别及病毒复制状况.结果 CHC患者血清中自身抗体至少一种阳性的32例,阳性率32.7%.ANA阳性率最高,为26.5%;其次为RF阳性率(8.1%),再次为AMA阳性率(2.0%),LC-1及LKM-1阳性率为1.0%.另外,自身抗体阳性组和阴性组有关因素比较发现,阳性组年龄较大(57.1岁vs 46.8岁),女性多见(65.6%vs 47.0%).肝脏功能差,免疫功能异常,病毒复制活跃.结论 丙型肝炎病毒(HCV)感染者存在自身免疫反应.HCV感染使感染者体内产生多种自身抗体,自身抗体检出率与年龄关系密切且与病毒的复制有关.自身抗体可能是HCV感染后肝组织损伤的重要因素.
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